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SML3716

MS6105

Name: MS6105
Brand: SIGMA

≥98% (HPLC)

别名:

2-(5-(Cyclopropylmethyl)-3-(3-(6-(13-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-13-oxotridecanamido)hex-1-yn-1-yl)phenyl)-4-(4-sulfamoylbenzyl)-1H-pyrazol-1-yl)thiazole-4-carboxylic acid

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关于此项目

经验公式（希尔记法）:

C₆₅H₈₁N₉O₉S₃

化学文摘社编号:

2891709-58-1

分子量:

1228.59

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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属性

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

-10 to -25°C

SMILES string

O=C(NCCCCC#CC1=CC(C2=NN(C(CC3CC3)=C2CC4=CC=C(C=C4)S(N)(=O)=O)C5=NC(C(O)=O)=CS5)=CC=C1)CCCCCCCCCCCC(N[C@H](C(N6C[C@@H](C[C@H]6C(NCC7=CC=C(C=C7)C8=C(N=CS8)C)=O)O)=O)C(C)(C)C)=O

InChI

1S/C65H81N9O9S3/c1-43-59(85-42-69-43)48-30-26-47(27-31-48)39-68-61(78)55-38-50(75)40-73(55)62(79)60(65(2,3)4)71-57(77)23-16-11-9-7-5-6-8-10-15-22-56(76)67-34-17-13-12-14-19-44-20-18-21-49(35-44)58-52(36-45-28-32-51(33-29-45)86(66,82)83)54(37-46-24-25-46)7

InChI key

APEYSKGQWJKJAZ-LCLGPXMOSA-N

说明

Biochem/physiol Actions

Cell penetrant, potent and selective lactate dehydrogenase (LDH) degrader (PROTAC) that effectively degrades LDHA and LDHB in PANC1 cells

MS6105 is a cell penetrant, potent and selective lactate dehydrogenase (LDH) degrader (PROTAC) that effectively degrades LDHA and LDHB in multiple pancreatic cancer cell lines. MS6105 potently inhibits the proliferation of PANC1 cells.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Discovery of the First Lactate Dehydrogenase Proteolysis Targeting Chimera Degrader for the Treatment of Pancreatic Cancer.

Ning Sun et al.

Journal of medicinal chemistry, 66(1), 596-610 (2022-12-21)

Lactate dehydrogenase (LDH) is a key glycolytic enzyme and biomarker of aggressive cancers. LDHA and LDHB are two main LDH subunits, and both are frequently overexpressed in tumors and essential for tumor growth. A number of LDHA/B small-molecule inhibitors have

全球贸易项目编号

货号	GTIN
SML3716-5MG	04065269284291
SML3716-25MG	04065269284284

主要文件

MS6105

≥98% (HPLC)

选择尺寸

关于此项目

Quality Level

assay

form

color

solubility

storage temp.

SMILES string

InChI

InChI key

Biochem/physiol Actions

安全信息

存储类别

wgk

flash_point_f

flash_point_c

文件

分析证书(COA)

已有该产品？

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全球贸易项目编号