SML3727
WIC1
≥98% (HPLC)
别名:
N-[4-(4-Ethyl-1-piperazinyl)phenyl]-2-oxo-2H-1-benzopyran-3-carboxamide, Wnt Inhibitor Compound 1
登录 查看组织和合同定价。
选择规格
变更视图
关于此项目
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
yellow to brown
solubility
DMSO:methanol (1:1): 2 mg/mL, clear (Warmed)
storage temp.
-10 to -25°C
SMILES string
O=C1OC2=C(C=C1C(NC3=CC=C(N4CCN(CC4)CC)C=C3)=O)C=CC=C2
InChI key
YQXKWSNLAVFZJL-UHFFFAOYSA-N
Biochem/physiol Actions
Potent Wnt/β-catenin signaling inhibitor that reduces airway basal stem cell (ABSC) proliferation and induces ciliated cell differentiation.
WIC1 is a potent Wnt/β-catenin signaling inhibitor (IC50 = 10 nM against 24h 5 μM CHIR-induced BEAS2B TCF/LEF reporter activity) that reduces airway basal stem cell (ABSC) proliferation (92% reduction of 4d 2 μM CHIR-induced hABSC proliferation by 1 μM WIC1) and induces ciliated cell differentiation (by 1.9-fold on d14 with 100 nM WIC1; mABSCs under air-liquid interface (ALI) condition) by suppressing β-catenin Y489 phosphorylation (complete inhibition of 24h 5 μM CHIR-induced pY489 in BEAS2B by 1 μM WIC1) and TP63 expression (80% reduction of 9d 1 μM CHIR-induced TP63 in mABSC by 1 μM WIC1; 40% reduction of 48h 5 μM CHIR-induced TP63 in BEAS2B by 1 μM WIC1).
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable