SML3733
BAY-0069
≥98% (HPLC)
别名:
2-Bromo-N-[2-(4-ethylphenyl)-1,3-benzoxazol-5-yl]-5-nitrobenzamide, BAY 0069, BAY0069
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选择尺寸
关于此项目
经验公式（希尔记法）:
C22H16BrN3O4
化学文摘社编号:
分子量:
466.28
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
BAY-0069 is a potent and selective covalent PPARγ inverse agonist (IC50 = 0.22 nM, max inhibition = 88% by cell-based reporter assays) that induces interactions between the PPARγ ligand-binding domain (LBD) and the corepressor NCOR2 (EC50 = 9.6 nM, Emax = 620% by TR-FRET). BAY-0069 exhibits anti-proliferation efficacy against PPARγ-dependent growth in cultures (UM-UC9 IC50 = 2.5 nM, max inhibition = 72%).
Potent and selective covalent PPARγ inverse agonist with anti-proliferation efficacy against PPARγ-dependent growth in cultures.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Discovery and Structure-Based Design of Potent Covalent PPAR? Inverse-Agonists BAY-4931 and BAY-0069
Journal of medicinal chemistry, 65(21), 14843-14863 (2022)
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