SML3753
TH301
≥98% (HPLC)
别名:
1-(4-Chlorophenyl)-N-[2,6-dihydro-2-(4-methoxyphenyl)-5,5-dioxido-4H-thieno[3,4-c]pyrazol-3-yl]-cyclopentanecarboxamide
InChI
1S/C24H24ClN3O4S/c1-32-19-10-8-18(9-11-19)28-22(20-14-33(30,31)15-21(20)27-28)26-23(29)24(12-2-3-13-24)16-4-6-17(25)7-5-16/h4-11H,2-3,12-15H2,1H3,(H,26,29)
InChI key
DDCUCVXSGYHWRJ-UHFFFAOYSA-N
SMILES string
O=C(C1(CCCC1)C2=CC=C(Cl)C=C2)NC3=C(CS(C4)(=O)=O)C4=NN3C5=CC=C(OC)C=C5
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Circadian clock modulator that selectively stabilizes CRY2
TH301 is a circadian clock modulator that lengthens a circadian period in cells and tissues. It selectively stabilizes CRY2 through interaction with FAD-binding pocket. TH301 strongly enhanced brown adipocyte differentiation in culture. TH301 showed no or only minor effects on CKIδ, CKIα and CK2 activities in vitro.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Effects of cryptochrome-modulating compounds on circadian behavioural rhythms in zebrafish
Journal of Biochemistry, 171(5), 501-507 (2022)
Structural differences in the FAD-binding pockets and lid loops of mammalian CRY1 and CRY2 for isoform-selective regulation.
Proceedings of the National Academy of Sciences of the USA, 118(26), e2026191118-e2026191118 (2021)
Simon Miller et al.
Nature chemical biology, 16(6), 676-685 (2020-04-02)
CRY1 and CRY2 are essential components of the circadian clock controlling daily physiological rhythms. Accumulating evidences indicate distinct roles of these highly homologous proteins, in addition to redundant functions. Therefore, the development of isoform-selective compounds represents an effective approach towards
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