SML3779
Methotrexate disodium salt
≥98% (HPLC)
别名:
Amethopterin sodium, N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid disodium salt, Sodium methotrexate
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关于此项目
经验公式（希尔记法）:
C20H20N8Na2O5
化学文摘社编号:
分子量:
498.40
UNSPSC Code:
12352200
NACRES:
NA.21
MDL number:
SMILES string
[Na].[Na].N([C@@H](CCC(=O)O)C(=O)O)C(=O)c1ccc(cc1)N(Cc2nc3c(nc(nc3N)N)nc2)C
InChI key
HQRCOVOSZPGUCA-GXKRWWSZSA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to brown
solubility
H2O: 2 mg/mL, clear
storage temp.
-10 to -25°C
Quality Level
Biochem/physiol Actions
Folic acid antagonist that is used as an antineoplastic and antirheumatic drug
Methotrexate disodium salt is a potent is a folic acid antagonist that is used as an antineoplastic and antirheumatic drug. Methotrexate disodium salt is a potent inhibitor of dihydrofolate reductase.
Disclaimer
Hygroscopic
signalword
Danger
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2 - Muta. 2 - Repr. 1B - Skin Irrit. 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Marrubium alysson L. Ameliorated Methotrexate-Induced Testicular Damage in Mice through Regulation of Apoptosis and miRNA-29a Expression: LC-MS/MS Metabolic Profiling.
Plants (Basel, Switzerland), 11(17), 2309-2309 (2022)
The effects of drug transporters on the efficacy of methotrexate in the treatment of rheumatoid arthritis
Life Sciences, 268, 118907-118907 (2021)
Molecular basis for pharmacokinetics and pharmacodynamics of methotrexate in rheumatoid arthritis therapy
Drug Metabolism and Pharmacokinetics, 29(1), 12-19 (2014)
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