SML3787
Pexiganan acetate
≥98% (HPLC)
别名:
GIGKFLKKAKKFGKAFVKILKK-NH2 acetate, Gly-Ile-Gly-Lys-Phe-Leu-Lys-Lys-Ala-Lys-Lys-Phe-Gly-Lys-Ala-Phe-Val-Lys-Ile-lIe-Lys-Lys-NH2 acetate, MSI 78 acetate, MSI-78 acetate, MSI78 acetate
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关于此项目
经验公式（希尔记法）:
C122H210N32O22 · xC2H2O4
化学文摘社编号:
分子量:
2477.17 (free base basis)
UNSPSC代码:
12352200
NACRES:
NA.21
质量水平
方案
≥98% (HPLC)
表单
(Powder or Lyophilized powder or film)
储存条件
desiccated
颜色
white to off-white
储存温度
-10 to -25°C
生化/生理作用
Cationic antimicrobial peptide (AMP) with broad-spectrum activity against Gram-positive and Gram-negative bacteria.
Pexiganan (MSI-78) is a 22-aa synthetic cationic antimicrobial peptide (AMP), an analog of magainin found in the African clawed frog (Xenopus laevis). Pexiganan is effective against both Gram-positive (staphylococci MIC ≤16 µg/mL, streptococci & methicillin-resistant S. aureus MIC 8-64 µg/mL, S. pyrogenes MIC 16-256 µg/mL) and Gram-negative aerobes (MIC 4-32 µg/mL, E. cloacae MCI 1-128 µg/mL, A. faecalis 4-64 µg/mL) by disrupting bacteria cell wall or membrane.
免责声明
Hygroscopic
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Alexandro Rodríguez-Rojas et al.
Frontiers in immunology, 11, 1686-1686 (2020-11-03)
Cationic antimicrobial peptides (AMPs) are active immune effectors of multicellular organisms and are also considered as new antimicrobial drug candidates. One of the problems encountered when developing AMPs as drugs is the difficulty of reaching sufficient killing concentrations under physiological
P C Fuchs et al.
Antimicrobial agents and chemotherapy, 42(5), 1213-1216 (1998-05-21)
MSI-78 is a cationic peptide with broad-spectrum antimicrobial activity and is being developed as a topical agent. We compared the in vitro activity of MSI-78 with those of ofloxacin and other antibiotics against fresh clinical isolates. Based on MIC distribution
H M Lamb et al.
Drugs, 56(6), 1047-1052 (1999-01-08)
Pexiganan acetate (MSI 78) is a synthetic cationic peptide (22 amino acids) with antibacterial activity. It is an analogue of magainin 2, which is a host defence peptide isolated from frog skin. The drug is thought to act by disturbing
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