SML3789
MS67
≥98% (HPLC)
别名:
N-(2′-fluoro-5′-((2-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3dimethyl-1-oxobutan-2-yl)amino)-2-oxoethyl)carbamoyl)-4-((3S,5R)-3,4,5-trimethylpiperazin-1-yl)-[1,1′-biphenyl]-3-yl)-6-oxo 4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Quality Level
Biochem/physiol Actions
Cell penetrant, potent and selective WD40 repeat domain protein 5 (WDR5) degrader
MS67 is a cell penetrant, potent and selective WD40 repeat domain protein 5 (WDR5) degrader that effectively and selectively degrades WDR5 in human MLL-r AML and PDAC cells.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models
Science Translational Medicine, 13(613), eabj1578-eabj1578 (2021)
Human WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation.
Wesley L Cai et al.
eLife, 11 (2022-09-01)
Metastatic breast cancer remains a major cause of cancer-related deaths in women, and there are few effective therapies against this advanced disease. Emerging evidence suggests that key steps of tumor progression and metastasis are controlled by reversible epigenetic mechanisms. Using
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