SML3818

YL-939

Name: YL-939
Brand: SIGMA

≥98% (HPLC)

别名:

8-(3,6-dihydro-2H-pyran-4-yl)-2-phenyl-6-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-a]pyrazine

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关于此项目

经验公式（希尔记法）:

C₂₅H₂₆N₆O

化学文摘社编号:

3023925-68-7

分子量:

426.51

MDL number:

MFCD35066881

NACRES:

NA.28

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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SMILES string

C(N=C1C2=CCOCC2)(C3=CN(N=C3)C4CCNCC4)=CN5C1=NC(C6=CC=CC=C6)=C5

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

room temp

Quality Level

100

Biochem/physiol Actions

Cell penetrant, potent and selective ferroptosis inhibitor that targets prohibitin 2 (PHB2).
YL-939 is a cell penetrant, potent and selective ferroptosis inhibitor. YL-939 binds directly to prohibitin 2 (PHB2) hence promoting the expression of the iron storage protein ferritin thus reducing the iron content, thereby decreasing the susceptibility to ferroptosis. YL-939 effectively protects cells from ferroptosis.

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