SML3822
SA-15-P
≥98% (HPLC)
别名:
N-[4-[2-[2,5-Dimethyl-1-(phenylmethyl)-1H-pyrrol-3-yl]-2-oxoethoxy]phenyl]-2-furancarboxamide
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
LAG-3 (CD223) inhibitor that blocks LAG-3 interactions with both major histocompatibility complex class II (MHCII) and fibrinogen-like protein 1 (FGL1).
SA-15-P is a LAG-3 (CD223) inhibitor that blocks LAG-3 interactions with both major histocompatibility complex class II and fibrinogen-like protein 1 by cell-free (MHCII IC50 = 4.21 μM & FGL1 IC50 = 6.52 μM) and cell-based binding assays (IC50 ~15 μM against 150 ng/mL or 1.5 nM FGL1-hFc binding to stable LAG-3-expressing CHO-K1 cell line).
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Discovery of First-in-Class Small Molecule Inhibitors of Lymphocyte Activation Gene 3 (LAG-3)
ACS Medicinal Chemistry Letters, 14(5), 629-635 (2023)
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