SML3826
LW-3-254
≥98% (HPLC)
别名:
(3aR,4R,4aR,5aS,6S,6aS)-2-(4-(2-(3,5-dichlorophenyl)-2-oxoethoxy)phenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione, Analog 13
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关于此项目
经验公式（希尔记法）:
C25H19Cl2NO4
分子量:
468.33
NACRES:
NA.21
UNSPSC Code:
51111800
eCl@ss:
32160701
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
LW-3-254, a derivative of MM0299, is an orally bioavailable and blood-brain barrier penetrant, selective and potent inhibitor of lanosterol synthase (LSS) that exhibits anti-glioblastoma activity. LW-3-254 stimulates 24(S),25-epoxycholesterol (EPC) synthesis in GBM tumors, which induces toxicity in glioma stem-like cells. It potently inhibits Mut6 (Glioblastoma stem-like cells) cell growth by depleting cellular cholesterol.
Orally bioavailable and blood-brain barrier penetrant, selective and potent inhibitor of lanosterol synthase (LSS)
WGK
WGK 3
存储类别
11 - Combustible Solids
闪点 (F)
Not applicable
闪点 (°C)
Not applicable