SML3832
Alnustone
≥98% (HPLC)
别名:
(4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one
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关于此项目
经验公式（希尔记法）:
C19H18O
化学文摘社编号:
分子量:
262.35
UNSPSC Code:
12352200
NACRES:
NA.21
MDL number:
产品名称
Alnustone, ≥98% (HPLC)
SMILES string
O=C(CCc2ccccc2)\C=C\C=C\c1ccccc1
InChI
1S/C19H18O/c20-19(16-15-18-11-5-2-6-12-18)14-8-7-13-17-9-3-1-4-10-17/h1-14H,15-16H2/b13-7+,14-8+
InChI key
OWMJDOUOHDOUFG-FNCQTZNRSA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Alnustone is a diarylheptanoid isolated from Alpinia katsumadai Hayata, rhizomes of Curcuma xanthorrhiza and other plants that exhibits anti-hyperglycemic, anti-inflammatory, antihepatotoxic and antiemetic activities. Alnustone is a potent inhibitor of the Thyroid Adenoma Associated (THADA) function, which reverses THADA-induced β-cell dysfunction and ameliorate hyperglycemia in obese mice. It significantly decreases fed blood glucose and improved glucose tolerance in mice.
Diarylheptanoid isolated from Alpinia katsumadai Hayata and other plants that exhibits anti-hyperglycemic, anti-inflammatory, antihepatotoxic and antiemetic activities
Disclaimer
Hygroscopic
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Alnustone inhibits Streptococcus pneumoniae virulence by targeting pneumolysin and sortase A
Fitoterapia, 162, 105261-105261 (2022)
Three non-phenolic diarylheptanoids with anti-inflammatory activity from Curcuma xanthorrhiza
Planta Medica, 59(5), 451-454 (1993)
Yuqing Zhang et al.
Nature communications, 14(1), 1020-1020 (2023-02-24)
Impaired insulin secretion is a hallmark in type 2 diabetes mellitus (T2DM). THADA has been identified as a candidate gene for T2DM, but its role in glucose homeostasis remains elusive. Here we report that THADA is strongly activated in human
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