SML3856
Alisporivir
≥95% (HPLC)
别名:
Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)-6-octenoyl-(2S)-2-aminobutanoyl-N-methyl-D-alanyl-N-ethyl-L-valyl-L-valyl-N-methyl-L-leucyl], DEB025, Debio 025
InChI key
OLROWHGDTNFZBH-XEMWPYQTSA-N
SMILES string
N1([C@H](C(=O)N[C@H](C(=O)N([C@@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C1=O)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)C(C)C)CC)C)C)CC)[C@H](O)[C@@H](C\C=C\C)C)C
assay
≥95% (HPLC)
form
(Powder or Lyophilized powder or film)
color
white to off-white
storage temp.
-10 to -25°C
Quality Level
Biochem/physiol Actions
Alisporivir is a Cyclophilin A inhibitor with potent anti-hepatitis C virus (HCV) activity. Alisporivir has also been investigated for Duchenne muscular dystrophy.
Cyclophilin A inhibitor; anti-viral with potent anti-hepatitis C virus (HCV) activity
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Alisporivir rescues defective mitochondrial respiration in Duchenne muscular dystrophy
Pharmacological Research, 125(Pt B), 122-131 (2017)
DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A
PLoS ONE, 5(10) (2010)
Combating Intracellular Pathogens with Repurposed Host-Targeted Drugs
ACS infectious diseases, 4(2), 88-92 (2018)
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