SML3860
Conolidine
≥98% (HPLC)
别名:
(+)-Conolidine, (+)-Ervaticine, (2R,4E,5S)-4-Ethylidene-1,4,5,7-tetrahydro-2,5-ethano-2H-azocino[4,3-b]indol-6(3H)-one, Ervaticine
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: >2 mg/mL, clear
储存温度
-10 to -25°C
SMILES字符串
O=C(C1=C(C[N@](CC2)C/3)C4=C(C=CC=C4)N1)[C@@H]2C3=C(C)\[H]
InChI
1S/C17H18N2O/c1-2-11-9-19-8-7-12(11)17(20)16-14(10-19)13-5-3-4-6-15(13)18-16/h2-6,12,18H,7-10H2,1H3/b11-2-/t12-/m0/s1
InChI key
DBGBUYFOJXOYNY-RENATIMJSA-N
生化/生理作用
Natural analgesic that induces pain relieve though activation of atypical scavenger receptor for chemokines and opioid peptides ACKR3 (CXCR7).
Conolidine is a natural analgesic isolated from tropical flowering shrub Tabernaemontana divaricate, which exhibits potent analgesia in in vivo models of tonic and persistent pain. Conolidine induces pain relieve though activation of atypical scavenger receptor for chemokines and opioid peptides ACKR3 (CXCR7). It appears that conolidine inhibits scavenging functions of ACKR3 therefore increasing levels of endogenous opioid peptides.
Conolidine is a natural analgesic isolated from tropical flowering shrub Tabernaemontana divaricate, which exhibits potent analgesia in in vivo models of tonic and persistent pain. Conolidine induces pain relieve though activation of atypical scavenger receptor for chemokines and opioid peptides ACKR3 (CXCR7). It appears that conolidine inhibits scavenging functions of ACKR3 therefore increasing levels of endogenous opioid peptides.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
法规信息
新产品
历史批次信息供参考:
Saori Naoe et al.
The Journal of organic chemistry, 81(13), 5690-5698 (2016-06-09)
A total synthesis of (+)-conolidine has been achieved via the gold(I)-catalyzed cascade cyclization of a conjugated enyne. Remarkably, this strategy allowed for the simultaneous formation of the indole ring and the ethylidene-substituted piperidine moiety of (+)-conolidine under homogeneous gold catalysis
Conolidine: A Novel Plant Extract for Chronic Pain
Amber N Edinoff
Anesthesiology Keywords Review, 11(6) (2021)
The natural analgesic conolidine targets the newly identified opioid scavenger ACKR3/CXCR7.
Martyna Szpakowska et al.
Signal transduction and targeted therapy, 6(1), 209-209 (2021-06-03)
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