Methoxy-X04

Name: Methoxy-X04
Brand: SIGMA

≥98% (HPLC)

别名:

4,4′-(1E,1′E)-2,2′-(2-Methoxy-1,4-phenylene)bis(ethene-2,1-diyl)diphenol, 4,4′-[(2-Methoxy-1,4-phenylene)di-(1E)-2,1-ethenediyl]bisphenol, MX04, MXO4, MeO-X04, MeO-XO4, MeX04, MeXO4, Methoxy-XO4, MethoxyX04, MethoxyXO4

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About This Item

经验公式（希尔记法）:

C₂₃H₂₀O₃

CAS Number:

863918-78-9

分子量:

344.40

MDL编号:

MFCD25563254

UNSPSC代码:

12352200

NACRES:

NA.77

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

, Faint yellow to dark orange

溶解性

DMSO: 2 mg/mL, clear

储存温度

2-8°C

生化/生理作用

A blood-brain barrier-permeant probe for live amyloid plaques imaging by fluorescent 2-photon microscopy.

Methoxy-X04 (MeO-X04, MethoxyX04, MeX04, MX04) is a blood-brain barrier-permeant fluorescent probe derived from the Chrysamine G and Congo red scaffold that retains affinity toward amyloid beta (Aβ) fibrils (Ki = 25.3 nM/Chrysamine G and 26.8 nM/Methoxy-X04), while being much more lipophilic than Chrysamine G and Congo red. Methoxy-X04 stains Aβ plaques, tangles, and cerebrovascular amyloid in postmortem brain sections with good specificity and is commonly utilized for high-resolution fluorescent imaging of individual amyloid plaques in live animals by 2-photon microscopy (Ex. 750-800 nm; Em. 380-480, 500-540, and 560-650 nm) following i.v. or i.p. injection (5-10 mg/kg).