SML3866
SCR2682
≥98% (HPLC)
别名:
N-[4-(2-Bromo-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2,6-dimethylphenyl]-3,3-dimethylbutanamide
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
room temp
Quality Level
Biochem/physiol Actions
Potent and selective opener of neuronal Kv7/KCNQ/M-channels that activates the native M-current in rat hippocampal or cortical neurons
SCR2682 is potent and selective opener of neuronal Kv7/KCNQ/M-channels that activates the native M-current in rat hippocampal or cortical neurons. It reverses epileptic seizures in rodents. SCR2682 relieves mechanical allodynia and thermal hyperalgesia in rat models of pain.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Activation of Neuronal Voltage-Gated Potassium Kv7/KCNQ/M-Current by a Novel Channel Opener SCR2682 for Alleviation of Chronic Pain
Journal of Pharmacology and Experimental Therapeutics, 377(1), 20-28 (2021)
Electrophysiological and pharmacological characterization of a novel and potent neuronal Kv7 channel opener SCR2682 for antiepilepsy
Faseb Journal, 33(8), 9154-9166 (2019)
Attenuation of Epileptogenesis and Cognitive Deficits by a Selective and Potent Kv7 Channel Opener in Rodent Models of Seizures
Journal of Pharmacology and Experimental Therapeutics, 384(2), 315-325 (2023)
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