SML3873
Pip6 PARP-1 inhibitor
≥98% (HPLC)
别名:
(S)-4-(3-(3-(1,1-difluoroethyl)-6-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one
相关类别
生化/生理作用
Cell penetrant and potent inhibitor of PARP-1 that exhibits potent cytotoxicity in cancer cells.
Pip6 is a cell penetrant and potent inhibitor of PARP-1 (Poly (ADP-ribose) polymerase 1) that exhibits potent cytotoxicity in cancer cells. It appears that Pip6 improved cytotoxicity is due to enhanced target residence time on PARP-1.
Pip6 is a cell penetrant and potent inhibitor of PARP-1 (Poly (ADP-ribose) polymerase 1) that exhibits potent cytotoxicity in cancer cells. It appears that Pip6 improved cytotoxicity is due to enhanced target residence time on PARP-1.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Allosteric regulation of DNA binding and target residence time drive the cytotoxicity of phthalazinone-based PARP-1 inhibitors.
Cell Chemical Biology, 29(12), 1694-1708 (2022)
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