SML3877
SRI-32743
≥98% (HPLC)
别名:
2-(7-Methylimidazo[1,2-a]pyridin-6-yl)-N-(2-phenylbutyl)-4-quinazolinamine
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关于此项目
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
2-8°C
Biochem/physiol Actions
Allosteric modulator of monoamine transporters that acts as partial antagonists of dopamine uptake.
SRI-32743 is an allosteric modulator of monoamine transporters that acts as partial antagonists of dopamine uptake. SRI-32743 attenuates Tat (the HIV regulatory protein transactivator of transcription) induced inhibition of DAT-mediated dopamine uptake. Also, it alleviates the potentiation of cocaine reward in HIV-1 Tat transgenic mice.
SRI-32743 is an allosteric modulator of monoamine transporters that acts as partial antagonists of dopamine uptake. SRI-32743 attenuates Tat (the HIV regulatory protein transactivator of transcription) induced inhibition of DAT-mediated dopamine uptake. Also, it alleviates the potentiation of cocaine reward in HIV-1 Tat transgenic mice.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
SRI-32743, a novel allosteric modulator, attenuates HIV-1 Tat protein-induced inhibition of the dopamine transporter and alleviates the potentiation of cocaine reward in HIV-1 Tat transgenic mice
Neuropharmacology, 220, 109239-109239 (2022)
Novel Allosteric Modulator Southern Research Institute-32743 Reverses HIV-1 Transactivator of Transcription-Induced Increase in Dopamine Release in the Caudate Putamen of Inducible Transactivator of Transcription Transgenic Mice
Journal of Pharmacology and Experimental Therapeutics, 384(2), 306-314 (2023)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML3877-5MG | 04065270979940 |
| SML3877-25MG | 04065270979933 |
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