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SML3878

KMR-206

≥94% (HPLC)

别名:

6-(4-(2-fluoro-5-((4-oxo-7-(prop-1-yn-1-yl)-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1-yl)nicotinonitrile

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关于此项目

经验公式（希尔记法）:
C29H23FN6O2
化学文摘社编号:
2992741-10-1
分子量:
506.53
NACRES:
NA.21
Assay:
≥94% (HPLC)
Form:
powder
Quality level:
100
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Quality Level

100

assay

≥94% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(C1=CC(CC2=NNC(C3=C2C=C(C=C3)C#CC)=O)=CC=C1F)N4CCN(CC4)C5=NC=C(C=C5)C#N

Biochem/physiol Actions

Cell penetrant, potent, and selective inhibitor of PARP7 that inhibits auto-MARylation and induced IFN-β in mouse colon carcinoma.
KMR-206 is a cell penetrant, potent, and selective inhibitor of PARP7 that inhibits auto-MARylation and induced IFN-β in mouse colon carcinoma (CT-26) cells. Also increased PARP7 protein levels in CT-26 cells.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000463645
0000463644
0000463644
0000463645
0000398448

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Z G Jia et al.
Zhonghua zhong liu za zhi [Chinese journal of oncology], 9(2), 124-126 (1987-03-01)
CT guided percutaneous fine needle aspiration cytodiagnosis was performed on 30 patients with pancreatic and periampullary tumors in China-Japan Friendship Hospital from November 1984 to January 1986. In our series, 9 pancreatic head cancers, 4 pancreatic body and tail cancers

全球贸易项目编号

货号GTIN
SML3878-25MG04065272299701
SML3878-5MG04065272300018

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