SML3892
CB-6644
≥98% (HPLC)
别名:
CB6644, 5-Chloro-2-ethoxy-4-fluoro-N-(4-((3-(methoxymethyl)-1-oxo-6,7-dihydro-1H,5H-benzo[c]pyrazolo[1,2-a][1,2]diazepin-2-yl)amino)-2,2-dimethyl-4-oxobutyl)benzamide, CB 6644
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关于此项目
经验公式（希尔记法）:
C29H34ClFN4O5
化学文摘社编号:
分子量:
573.06
UNSPSC Code:
12352200
NACRES:
NA.21
MDL number:
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
CB-6644 is an orally active, non-ATP-competitive, potent and selective allosteric inhibitor against the RUVBL1/2 complex ATPase activity (IC50 = 15 nM; IC50 >100 μM against a panel of related AAA ATPases) with cancer killing potency in cultures (IC50 = 41-785 nM) and in xenograft myeloma models in vivo (150 mg/kg qd. or bid. via p.o.).
Orally active, potent and selective allosteric inhibitor against the RUVBL1/2 complex ATPase activity with cancer killing potency in cultures and in vivo.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
CB-6644 Is a Selective Inhibitor of the RUVBL1/2 Complex with Anticancer Activity
ACS Chemical Biology, 14(2), 236-244 (2019)
Rui Zhang et al.
Frontiers in immunology, 12, 679184-679184 (2021-07-20)
Macrophages play an important role in the host defense mechanism. In response to infection, macrophages activate a genetic program of pro-inflammatory response to kill any invading pathogen, and initiate an adaptive immune response. We have identified RUVBL2 - an ATP-binding
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