SMILES string
O=C(C1=CN(C2=CC=C(C(NC3=CC=CC=C3)=O)C=C2)N=N1)NCC4=CC=CS4
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Allosteric site-targeting macrophage migration inhibitory factor (MIF) inhibitor that protects HeLa cells against MNNG-induced parthanatos.
MKA031 is an allosteric site-targeting macrophage migration inhibitory factor inhibitor (MIF tautomerase activity IC50 = 1.7 μM) that prevents MNNG-induced MIF nuclear translocation (3h 100 μM MKA031 preincubation prior to 15-min 50 μM MNNG treatment; HeLa cells) by interfering with MIF/AIF interaction (IC50 = 12.3 μM against 4 μM AIF in wells precoated with 100 μL of a 250 nM MIF solution). Unlike ZP143, MKA031 protects HeLa cells against MNNG-induced parthanatos (EC50 = 7.7 μM 24h post 15-min 50 μM MNNG treatment).
MKA031 is an allosteric site-targeting macrophage migration inhibitory factor inhibitor (MIF tautomerase activity IC50 = 1.7 μM) that prevents MNNG-induced MIF nuclear translocation (3h 100 μM MKA031 preincubation prior to 15-min 50 μM MNNG treatment; HeLa cells) by interfering with MIF/AIF interaction (IC50 = 12.3 μM against 4 μM AIF in wells precoated with 100 μL of a 250 nM MIF solution). Unlike ZP143, MKA031 protects HeLa cells against MNNG-induced parthanatos (EC50 = 7.7 μM 24h post 15-min 50 μM MNNG treatment).
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