SML3923
NU7441
≥98% (HPLC)
别名:
8-Dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one, NU 7441, NU-7441
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关于此项目
经验公式（希尔记法）:
C25H19NO3S
化学文摘社编号:
分子量:
413.49
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
2-8°C
SMILES string
[s]1c2c(c6c1cccc6)cccc2c3c4[o]c(c[c](c4ccc3)=O)N5CCOCC5
InChI
1S/C25H19NO3S/c27-21-15-23(26-11-13-28-14-12-26)29-24-17(6-3-9-20(21)24)19-8-4-7-18-16-5-1-2-10-22(16)30-25(18)19/h1-10,15H,11-14H2
InChI key
JAMULYFATHSZJM-UHFFFAOYSA-N
Biochem/physiol Actions
Potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor in vitro and in vivo.
NU7441 is a potent and selective DNA-dependent protein kinase inhibitor (DNA-PK IC50 = 14 nM; IC50 = 1.7 μM/mTOR, 5 μM/PI3Kα, >100 μM/ATM & ATR) that effectively sensitizes cancer cells to the cytotoxic effects of both ionizing radiation and the topoisomerase II inhibitor etoposide in cultures (0.5 μM; SW620 & LoVo cells) and in vivo (10 mg/kg via daily i.p. in mice with human colon cancer SW620 xenografts).
NU7441 is a potent and selective DNA-dependent protein kinase inhibitor (DNA-PK IC50 = 14 nM; IC50 = 1.7 μM/mTOR, 5 μM/PI3Kα, >100 μM/ATM & ATR) that effectively sensitizes cancer cells to the cytotoxic effects of both ionizing radiation and the topoisomerase II inhibitor etoposide in cultures (0.5 μM; SW620 & LoVo cells) and in vivo (10 mg/kg via daily i.p. in mice with human colon cancer SW620 xenografts).
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable