SML3928
Bodilisant
≥98% (HPLC)
别名:
5,5-difluoro-1,3,7,9-tetramethyl-10-(4-(3-(piperidin-1-yl)propoxy)phenyl)-5H-4l4,5l4-dipyrrolo[1,2-c:2′,1′-f][1,3,2]diazaborinine
生化/生理作用
High affinity histamine H3 receptor fluorescent ligand suitable to visualize H3 receptor in cells.
Bodilisant is a high affinity histamine H3 receptor fluorescent ligand suitable to visualize H3 receptor in cells. Bodilisant was successfully used to determine drug-target residence times for the H3 receptor ligands.
Bodilisant is a high affinity histamine H3 receptor fluorescent ligand suitable to visualize H3 receptor in cells. Bodilisant was successfully used to determine drug-target residence times for the H3 receptor ligands.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
David Reiner et al.
European journal of pharmacology, 848, 112-120 (2019-02-01)
Growing evidence recommends incorporating the concept of drug-target residence times within drug development and screening programs. For many targets, systematic research for binding kinetics is emerging and reported, as in case of the histamine H3 receptor. Alternatively, fluorescent methods based
Miriam Tomasch et al.
ACS medicinal chemistry letters, 4(2), 269-273 (2013-02-14)
A piperidine-based lead structure for the human histamine H3 receptor (hH3R) was coupled with the BODIPY fluorophore and resulted in a strong green fluorescent (quantum yield, 0.92) hH3R ligand with affinity in the nanomolar concentration range (K i hH3R =
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