质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
COC1=CC=C(C2(CC2)NCC3=CNN=C3C4=CC=CS4)C=C1
InChI
1S/C18H19N3OS/c1-22-15-6-4-14(5-7-15)18(8-9-18)19-11-13-12-20-21-17(13)16-3-2-10-23-16/h2-7,10,12,19H,8-9,11H2,1H3,(H,20,21)
InChI key
CXRMCTBDMZVPNE-UHFFFAOYSA-N
相关类别
生化/生理作用
Cell penetrant, potent and selective inhibitor of Plasmodium falciparum myosin A (PfMyoA) and Toxoplasma gondii myosin A (TgMyoA).
KNX-002 is a cell penetrant, potent and selective inhibitor of Plasmodium falciparum myosin A (PfMyoA) and Toxoplasma gondii myosin A (TgMyoA) that has no or little effect on the vertebrate myosins tested. KNX-002 obstructs efficient ATP hydrolysis thus inhibiting motor activity. KNX-002 inhibits parasite motility and growth.
KNX-002 is a cell penetrant, potent and selective inhibitor of Plasmodium falciparum myosin A (PfMyoA) and Toxoplasma gondii myosin A (TgMyoA) that has no or little effect on the vertebrate myosins tested. KNX-002 obstructs efficient ATP hydrolysis thus inhibiting motor activity. KNX-002 inhibits parasite motility and growth.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Anne Kelsen et al.
PLoS biology, 21(5), e3002110-e3002110 (2023-05-08)
Toxoplasma gondii is a widespread apicomplexan parasite that can cause severe disease in its human hosts. The ability of T. gondii and other apicomplexan parasites to invade into, egress from, and move between cells of the hosts they infect is
Dihia Moussaoui et al.
Nature communications, 14(1), 3463-3463 (2023-06-13)
Malaria results in more than 500,000 deaths per year and the causative Plasmodium parasites continue to develop resistance to all known agents, including different antimalarial combinations. The class XIV myosin motor PfMyoA is part of a core macromolecular complex called
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持