SML3943
LL-K9-3
≥98% (HPLC)
别名:
N-(5-(((5-(tert-Butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-1-((2-(2-(((1R, 2S, 5R)-2-isopropyl-5-methylcyclohexyl)oxy)acetamido)ethyl)sulfonyl)piperidine-4-carboxamide
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
-10 to -25°C
SMILES字符串
O=S(CCNC(CO[C@H]1[C@H](C(C)C)CC[C@@H](C)C1)=O)(N2CCC(C(NC3=NC=C(S3)SCC4=NC=C(O4)C(C)(C)C)=O)CC2)=O
InChI
1S/C31H49N5O6S3/c1-20(2)23-8-7-21(3)15-24(23)41-18-26(37)32-11-14-45(39,40)36-12-9-22(10-13-36)29(38)35-30-34-17-28(44-30)43-19-27-33-16-25(42-27)31(4,5)6/h16-17,20-24H,7-15,18-19H2,1-6H3,(H,32,37)(H,34,35,38)/t21-,23+,24-/m1/s1
InChI key
NPRIWHDFWDSJRZ-YFNKSVMNSA-N
生化/生理作用
Potent and selective CDK9-cyclin T1 complex degrader with stronger inhibition than THAL-SNS-032 against oncogenic transcription driven by Myc and AR.
LL-K9-3 is a potent and selective CDK9-cyclin T1 complex degrader (CDK9/CycT1 DC50 = 662/589 nM post 24h treatment, 22RV1 cells) with little potency toward other CDKs (1, 2, 4-7) or cyclins (E1, H, T2). LL-K9-3 exhibits higher antiproliferation activity than SNS-032 against 22RV1 prostate carcinoma cell (IC50 = 95 vs. 384 nM post 5-day treatment). Comparing to SNS-032 and THAL-SNS-032, LL-K9-3 shows stronger inhibition against oncogenic transcription driven by Myc and AR, as well as on several AR intrinsic target genes.
LL-K9-3 is a potent and selective CDK9-cyclin T1 complex degrader (CDK9/CycT1 DC50 = 662/589 nM post 24h treatment, 22RV1 cells) with little potency toward other CDKs (1, 2, 4-7) or cyclins (E1, H, T2). LL-K9-3 exhibits higher antiproliferation activity than SNS-032 against 22RV1 prostate carcinoma cell (IC50 = 95 vs. 384 nM post 5-day treatment). Comparing to SNS-032 and THAL-SNS-032, LL-K9-3 shows stronger inhibition against oncogenic transcription driven by Myc and AR, as well as on several AR intrinsic target genes.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Jiacheng Li et al.
Journal of medicinal chemistry, 65(16), 11034-11057 (2022-08-05)
Aberrant hyperactivation of cyclins results in carcinogenesis and therapy resistance in cancers. Direct degradation of the specific cyclin or cyclin-dependent kinase (CDK)-cyclin complex by small-molecule degraders remains a great challenge. Here, we applied the first application of hydrophobic tagging to
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