SML3951
NSC255112
≥90% (HPLC)
别名:
NSC255112, 19-[(4-Morpholinylimino)methyl]-geldanamycin, NSC 255112
InChI
1S/C34H48N4O10/c1-19-15-23-29(40)27(24(30(41)32(23)46-7)18-36-38-11-13-47-14-12-38)37-33(42)20(2)9-8-10-25(44-5)31(48-34(35)43)22(4)17-21(3)28(39)26(16-19)45-6/h8-10,17-19,21,25-26,28,31,39H,11-16H2,1-7H3,(H2,35,43)(H,37,42)/b10-8-,20-9-,22-17-,36-18+/t19
InChI key
NBLSLHGULNLUQD-PRIZTHDISA-N
SMILES string
O=C(C(NC(/C(C)=C/C=C\[C@H](OC)[C@H]1OC(N)=O)=O)=C2/C=N/N3CCOCC3)C(C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C1\C)=C(OC)C2=O
assay
≥90% (HPLC)
form
powder
color
, Light red to dark purple
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
-10 to -25°C
Quality Level
Biochem/physiol Actions
Cell penetrant and potent global inhibitor of cellular glycosylation that induces reversible Golgi fragmentation.
NSC255112 is a cell penetrant and potent global inhibitor of cellular glycosylation that induces reversible Golgi fragmentation. NSC80997 affects both initiation and elongation of O-glycosylation in ways not directly dependent on GalNAc-T11. NSC255112 induces Tn antigen expression in human cell lines. It also reduces cell surface heparan sulfate a necessary factor for SARS-CoV-2 infection.
NSC255112 is a cell penetrant and potent global inhibitor of cellular glycosylation that induces reversible Golgi fragmentation. NSC80997 affects both initiation and elongation of O-glycosylation in ways not directly dependent on GalNAc-T11. NSC255112 induces Tn antigen expression in human cell lines. It also reduces cell surface heparan sulfate a necessary factor for SARS-CoV-2 infection.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Daniel Madriz Sørensen et al.
Nature communications, 14(1), 948-948 (2023-02-23)
Small molecule inhibitors of glycosylation enzymes are valuable tools for dissecting glycan functions and potential drug candidates. Screening for inhibitors of glycosyltransferases are mainly performed by in vitro enzyme assays with difficulties moving candidates to cells and animals. Here, we
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