SML3981
CITFA
≥98% (HPLC)
别名:
2-Cyclohexyl-4-isopropyl-N-((5-(tetrahydro-2H-pyran-2-yl)furan-2-yl)methyl)aniline, N-[2-Cyclohexyl-4-(1-methylethyl)phenyl]-5-(tetrahydro-2H-pyran-2-yl)-2-furanmethanamine
InChI
1S/C25H35NO2/c1-18(2)20-11-13-23(22(16-20)19-8-4-3-5-9-19)26-17-21-12-14-25(28-21)24-10-6-7-15-27-24/h11-14,16,18-19,24,26H,3-10,15,17H2,1-2H3
InChI key
GYTVCHRGONLGMD-UHFFFAOYSA-N
SMILES string
CC(C)C(C=C1C2CCCCC2)=CC=C1NCC3=CC=C(C4OCCCC4)O3
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Potent and selective G protein-coupled estrogen receptor (GPER) agonist with significantly higher potency than G-1 and greater selectivity than 17β-estradiol (E2).
CITFA is a potent and selective G protein-coupled estrogen receptor (GPER) agonist that specifically inudces calcium mobilizaton in GPER-transfected, but not non-transfected, COS cells. CITFA is more potent than G-1 (Ca2+ EC50 = 38.7 nM vs. 1.71 μM in HL-60 cells) and, unlike 17β-estradiol (E2), exhibits no affinity toward ERα/β (Ki >10 μM). CITFA (100 nM for 72h) significantly increases axonal and dendritic growth in rat embryonic (E18) hippocampal neurons.
CITFA is a potent and selective G protein-coupled estrogen receptor (GPER) agonist that specifically inudces calcium mobilizaton in GPER-transfected, but not non-transfected, COS cells. CITFA is more potent than G-1 (Ca2+ EC50 = 38.7 nM vs. 1.71 μM in HL-60 cells) and, unlike 17β-estradiol (E2), exhibits no affinity toward ERα/β (Ki >10 μM). CITFA (100 nM for 72h) significantly increases axonal and dendritic growth in rat embryonic (E18) hippocampal neurons.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Novel GPER Agonist, CITFA, Increases Neurite Growth in Rat Embryonic (E18) Hippocampal Neurons
ACS Chemical Neuroscience, 13(8), 1119-1128 (2022)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持