SMILES string
O=C(O)[C@H]1[C@@H](C1)C2=NC(C3=CC=CC=C3)=C(O2)C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Potent and selective retinoid X receptors (RXRs) agonist that activates cellular RXR homodimer as well as RXR:RAR heterodimer.
JP3000 is a potent and selective retinoid X receptors agonist (EC50/Emax = 5 nM/38-fold/RXRα 1.4 nM/69-fold/RXRβ, 4 nM/24-fold/RXRγ) with >100-fold selecivity for RXR over a panel of 27 other nuclear receptors (little or no activation at 1 µM). JP3000 activates cellular RXR homodimer as well as RXR:RAR heterodimer (EC50 = 2.6 and 29 nM, respectively), and induces RXR-regulated GDE1 gene expression (by 2.3-fold/10 nM & 3.6-fold/100 nM).
JP3000 is a potent and selective retinoid X receptors agonist (EC50/Emax = 5 nM/38-fold/RXRα 1.4 nM/69-fold/RXRβ, 4 nM/24-fold/RXRγ) with >100-fold selecivity for RXR over a panel of 27 other nuclear receptors (little or no activation at 1 µM). JP3000 activates cellular RXR homodimer as well as RXR:RAR heterodimer (EC50 = 2.6 and 29 nM, respectively), and induces RXR-regulated GDE1 gene expression (by 2.3-fold/10 nM & 3.6-fold/100 nM).
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