SML3996
Pentachloropseudilin
≥98% (HPLC)
别名:
2,4-Dichloro-6-(3,4,5-trichloro-1H-pyrrol-2-yl)phenol, 2,4-Dichloro-6-(3,4,5-trichloro-2-pyrrolyl)phenol, Antibiotic A 15104Y, PClP
InChI
1S/C10H4Cl5NO/c11-3-1-4(9(17)5(12)2-3)8-6(13)7(14)10(15)16-8/h1-2,16-17H
InChI key
FBRLLYYPGGXCKT-UHFFFAOYSA-N
SMILES string
OC1=C(C2=C(Cl)C(Cl)=C(Cl)N2)C=C(Cl)C=C1Cl
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Quality Level
Biochem/physiol Actions
Reversible allosteric inhibitor of myosin ATPase and motor activity specific for class-1 myosin; inhibits T. cruzi parasite motility.
Pentachloropseudilin is a reversible allosteric inhibitor of myosin ATPase and motor activity specific for class-1 myosin. Pentachloropseudilin is a natural product present in marine bacteria Chromobacterium sp., Pseudomonas bromoutilis, and Alteromonas luteoviolaceus. Pentachloropseudilin inhibits T. cruzi parasite motility, host cell adhesion and invasion.
Pentachloropseudilin is a reversible allosteric inhibitor of myosin ATPase and motor activity specific for class-1 myosin. Pentachloropseudilin is a natural product present in marine bacteria Chromobacterium sp., Pseudomonas bromoutilis, and Alteromonas luteoviolaceus. Pentachloropseudilin inhibits T. cruzi parasite motility, host cell adhesion and invasion.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Krishna Chinthalapudi et al.
The Journal of biological chemistry, 286(34), 29700-29708 (2011-06-18)
Here, we report that the natural compound pentachloropseudilin (PClP) acts as a reversible and allosteric inhibitor of myosin ATPase and motor activity. IC(50) values are in the range from 1 to 5 μm for mammalian class-1 myosins and greater than
Myosin 1c: A novel regulator of glucose uptake in brown adipocytes
Molecular Metabolism (2021)
Mylla Spirandelli da Costa et al.
Chembiochem : a European journal of chemical biology, 23(18), e202200349-e202200349 (2022-07-16)
Pentachloropseudilin (PClP) is a reversible and allosteric inhibitor of type 1 myosin. Here, we addressed the impact of PClP treatment of Trypanosoma cruzi and mammalian host cell on the parasite migration, cell adhesion and invasion. We observed that PClP was not
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