SMILES string
O=C([C@H]1N(C([C@H](NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@@H](N2)[C@H](C)O)=O)=O)=O)CC3=CC=CC=C3)=O)CCC1)N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](CC4=CC=CC=C4)C(N[C@H](C2=O)C)=O)=O)=O)CCCNC(N)=N)=O)C(C)C
assay
≥95% (HPLC)
form
(Powder or Lyophilized powder or film)
color
white to off-white
storage temp.
-10 to -25°C
Quality Level
Biochem/physiol Actions
In vivo active specific cyclic GMP-AMP synthase (cGAS) inhibitor that binds to DNA binding site of cGAS.
XQ2B, macrocyclic peptide derived from Gramicidin S, acts a specific cyclic GMP-AMP synthase (cGAS) inhibitor by directly targeting protein-DNA interface. XQ2B attenuates the host innate antiviral response.
XQ2B, macrocyclic peptide derived from Gramicidin S, acts a specific cyclic GMP-AMP synthase (cGAS) inhibitor by directly targeting protein-DNA interface. XQ2B attenuates the host innate antiviral response.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Development of cyclopeptide inhibitors of cGAS targeting protein-DNA interaction and phase separation
Nature Communications, 14(1), 6132-6132 (2023)
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