SML4035
CGP 78608 hydrochloride
≥97%
别名:
CGP 78608 hydrochloride, CGP-78608 hydrochloride, CGP78608 hydrochloride, PAMQX hydrochloride, [(1S)-1-[[(7-Bromo-1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl]amino]ethyl]phosphonate, hydrochloride, P-[(1S)-1-[[(7-Bromo-1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl]amino]ethyl]phosphonic acid, hydrochloride (1:1)
质量水平
方案
≥97%
表单
powder
储存条件
desiccated
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear (warmed)
储存温度
-10 to -25°C
SMILES字符串
BrC1=CC(NC2=O)=C(C(CN[C@@H](P(O)(O)=O)C)=C1)NC2=O.Cl
生化/生理作用
Potent glycine site-selective NMDA receptor antagonist with anticonvulsant efficacy in vivo.
CGP 78608 (PAMQX) is a potent glycine site-selective NMDA receptor antagonist (IC50 = 5 nM by competitive binding against 5 nM [3H]MDL 105,519; IC50 = 3/2.7 μM against AMPA/kainate, >10 μM against CGP39653 (glutamate site) and channel blocker MK-801) that exhibits anticonvulsant efficacy in mice in vivo (electroshock-induced convulsion ED50 = 12 mg/kg i.p.).
CGP 78608 (PAMQX) is a potent glycine site-selective NMDA receptor antagonist (IC50 = 5 nM by competitive binding against 5 nM [3H]MDL 105,519; IC50 = 3/2.7 μM against AMPA/kainate, >10 μM against CGP39653 (glutamate site) and channel blocker MK-801) that exhibits anticonvulsant efficacy in mice in vivo (electroshock-induced convulsion ED50 = 12 mg/kg i.p.).
免责声明
Hygroscopic
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
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