SML4035

CGP 78608 hydrochloride

Name: CGP 78608 hydrochloride
Brand: SIGMA

≥97%

别名:

CGP 78608 hydrochloride, CGP-78608 hydrochloride, CGP78608 hydrochloride, PAMQX hydrochloride, [(1S)-1-[[(7-Bromo-1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl]amino]ethyl]phosphonate, hydrochloride, P-[(1S)-1-[[(7-Bromo-1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl]amino]ethyl]phosphonic acid, hydrochloride (1:1)

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关于此项目

经验公式（希尔记法）:

C₁₁H₁₃BrN₃O₅P·HCl

化学文摘社编号:

1135278-54-4

分子量:

414.58

MDL number:

MFCD06798371

NACRES:

NA.21

Assay:

≥97%

Form:

powder

Quality level:

100

Storage condition:

desiccated

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SMILES string

BrC1=CC(NC2=O)=C(C(CN[C@@H](P(O)(O)=O)C)=C1)NC2=O.Cl

assay

≥97%

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

-10 to -25°C

Quality Level

100

Biochem/physiol Actions

Potent glycine site-selective NMDA receptor antagonist with anticonvulsant efficacy in vivo.
CGP 78608 (PAMQX) is a potent glycine site-selective NMDA receptor antagonist (IC50 = 5 nM by competitive binding against 5 nM [3H]MDL 105,519; IC50 = 3/2.7 μM against AMPA/kainate, >10 μM against CGP39653 (glutamate site) and channel blocker MK-801) that exhibits anticonvulsant efficacy in mice in vivo (electroshock-induced convulsion ED50 = 12 mg/kg i.p.).