SML4036
AN3661
≥98% (HPLC)
别名:
1,3-Dihydro-1-hydroxy-2,1-benzoxaborole-7-propanoic acid, 3-(1-Hydroxy-1,3-dihydro-2,1-benzoxaborol-7-yl)propanoic acid; 3-(1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-7-yl)propanoicacid
InChI
1S/C10H11BO4/c12-9(13)5-4-7-2-1-3-8-6-15-11(14)10(7)8/h1-3,14H,4-6H2,(H,12,13)
InChI key
CEVOKIPNIZQANN-UHFFFAOYSA-N
SMILES string
OC(CCC1=CC=CC2=C1B(OC2)O)=O
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Boron containing antimalarial agent that targets Plasmodium falciparum CPSF3 (cleavage and polyadenylation specific factor 3).
AN3661 is a boron containing antimalarial agent that targets Plasmodium falciparum CPSF3 (cleavage and polyadenylation specific factor 3). AN3661potently inhibits Plasmodium falciparum laboratory-adapted strains (mean IC50=32 nM). Also, AN3661 inhibits T. gondii growth in human cells at low micromolar concentrations.
AN3661 is a boron containing antimalarial agent that targets Plasmodium falciparum CPSF3 (cleavage and polyadenylation specific factor 3). AN3661potently inhibits Plasmodium falciparum laboratory-adapted strains (mean IC50=32 nM). Also, AN3661 inhibits T. gondii growth in human cells at low micromolar concentrations.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Saiqi Hao et al.
Plant physiology, 193(1), 537-554 (2023-06-19)
Cleavage and polyadenylation specificity factor (CPSF) is a protein complex that plays an essential biochemical role in mRNA 3'-end formation, including poly(A) signal recognition and cleavage at the poly(A) site. However, its biological functions at the organismal level are mostly
Transcriptional dynamics in the protozoan parasite Sarcocystis neurona and mammalian host cells after treatment with a specific inhibitor of apicomplexan mRNA polyadenylation
PLoS ONE, 16(10) (2021)
Andrés Palencia et al.
EMBO molecular medicine, 9(3), 385-394 (2017-02-06)
Toxoplasma gondii is an important food and waterborne pathogen causing toxoplasmosis, a potentially severe disease in immunocompromised or congenitally infected humans. Available therapeutic agents are limited by suboptimal efficacy and frequent side effects that can lead to treatment discontinuation. Here
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