SML4037
ASP7967
≥98% (HPLC)
别名:
N2,N4-bis(4-Fluorophenyl)-N6-(2-pyrimidinylmethyl)-1,3,5-triazine-2,4,6-triamine
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关于此项目
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
FC1=CC=C(NC2=NC(NCC3=NC=CC=N3)=NC(NC4=CC=C(C=C4)F)=N2)C=C1
InChI key
UAAKDZMQDFXQTN-UHFFFAOYSA-N
Biochem/physiol Actions
Cell permeable, low-toxic triazine-triamine ligand of the RNA aptamer AC17-4 that effectively activates gene expression in riboswitches and significantly raises hEPO levels in mice.
ASP7967 is a cell permeable, low-toxic triazine-triamine ligand of the RNA aptamer AC17-4 with a Kd of 12 nM and an EC50 of 2.3 µM. ASP-7967 significantly activates gene expression in aptazyme-based riboswitches, exceeding a tenfold increase in HEK293 cells. Furthermore, when administered orally at 100 mg/kg, ASP 7967 substantially boosts serum human erythropoietin (hEPO) levels in mice, about 7.2 times more than the control, demonstrating its robust in vivo effectiveness.
ASP7967 is a cell permeable, low-toxic triazine-triamine ligand of the RNA aptamer AC17-4 with a Kd of 12 nM and an EC50 of 2.3 µM. ASP-7967 significantly activates gene expression in aptazyme-based riboswitches, exceeding a tenfold increase in HEK293 cells. Furthermore, when administered orally at 100 mg/kg, ASP 7967 substantially boosts serum human erythropoietin (hEPO) levels in mice, about 7.2 times more than the control, demonstrating its robust in vivo effectiveness.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable