SML4037
ASP7967
≥98% (HPLC)
别名:
N2,N4-bis(4-Fluorophenyl)-N6-(2-pyrimidinylmethyl)-1,3,5-triazine-2,4,6-triamine
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
FC1=CC=C(NC2=NC(NCC3=NC=CC=N3)=NC(NC4=CC=C(C=C4)F)=N2)C=C1
InChI key
UAAKDZMQDFXQTN-UHFFFAOYSA-N
生化/生理作用
Cell permeable, low-toxic triazine-triamine ligand of the RNA aptamer AC17-4 that effectively activates gene expression in riboswitches and significantly raises hEPO levels in mice.
ASP7967 is a cell permeable, low-toxic triazine-triamine ligand of the RNA aptamer AC17-4 with a Kd of 12 nM and an EC50 of 2.3 µM. ASP-7967 significantly activates gene expression in aptazyme-based riboswitches, exceeding a tenfold increase in HEK293 cells. Furthermore, when administered orally at 100 mg/kg, ASP 7967 substantially boosts serum human erythropoietin (hEPO) levels in mice, about 7.2 times more than the control, demonstrating its robust in vivo effectiveness.
ASP7967 is a cell permeable, low-toxic triazine-triamine ligand of the RNA aptamer AC17-4 with a Kd of 12 nM and an EC50 of 2.3 µM. ASP-7967 significantly activates gene expression in aptazyme-based riboswitches, exceeding a tenfold increase in HEK293 cells. Furthermore, when administered orally at 100 mg/kg, ASP 7967 substantially boosts serum human erythropoietin (hEPO) levels in mice, about 7.2 times more than the control, demonstrating its robust in vivo effectiveness.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Keisuke Fukunaga et al.
Journal of the American Chemical Society, 145(14), 7820-7828 (2023-03-31)
Synthetic riboswitches that can regulate gene expression by a small molecule recognized by an RNA aptamer in mammalian cells have various potential applications in biotechnology and medicine. However, the variety of small molecules and their cognate aptamers that have been
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