assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Cyclic nucleotide suppressor.
CNTinh-03 is a small-molecule general suppressors of cellular cyclic nucleotides. It reduces basal and agonist-induced elevation of cytoplasmic cAMP and cGMP in multiple cells and in response to different types of agonists. The mechanism of action involves nonselective activation of phosphodiesterase (PDE).
CNTinh-03 is a small-molecule general suppressors of cellular cyclic nucleotides. It reduces basal and agonist-induced elevation of cytoplasmic cAMP and cGMP in multiple cells and in response to different types of agonists. The mechanism of action involves nonselective activation of phosphodiesterase (PDE).
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Lukmanee Tradtrantip et al.
Molecular pharmacology, 75(1), 134-142 (2008-10-01)
We carried out a "pathway" screen of 50,000 small molecules to identify novel modulators of cAMP signaling. One class of compounds, the 2-(acylamino)-3-thiophenecarboxylates, strongly suppressed cAMP and cGMP in multiple cell lines in response to different agonists acting on G-protein-coupled
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