SMILES string
O=C(C1=CC=C(NC(NCCN2CCOCC2)=O)C=C1)/C=C/C3=CC=CC(N4CCOCC4)=N3
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Potent heat shock protein 70 inducer with therapeutic efficacy in a rat model of transient cerebral ischemia in vivo.
TRC051384 is a potent heat shock protein 70 inducer (fold of HSP70 mRNA induction in 4h at 6.25/12.5 µM = 19/210 in HeLa & 10/84 in primary neonatal rat cerebellum neurons) that increases HSF1 transcriptional activity in HeLa cells (by 2.1/3.3-fold at 12.5/2.5 µM) and reduces LPS-induced TNF-α expression in THP-1 cells (% inhibition/conc. = 60/6.25 µM & 90/12.5 µM). TRC051384 reduces neuronal injury and disability in a rat model of transient cerebral ischemia in vivo (9 mg/kg 4h or 8h post onset of ischemia, then 4.5 mg/kg every 2h for 48h via i.p.).
TRC051384 is a potent heat shock protein 70 inducer (fold of HSP70 mRNA induction in 4h at 6.25/12.5 µM = 19/210 in HeLa & 10/84 in primary neonatal rat cerebellum neurons) that increases HSF1 transcriptional activity in HeLa cells (by 2.1/3.3-fold at 12.5/2.5 µM) and reduces LPS-induced TNF-α expression in THP-1 cells (% inhibition/conc. = 60/6.25 µM & 90/12.5 µM). TRC051384 reduces neuronal injury and disability in a rat model of transient cerebral ischemia in vivo (9 mg/kg 4h or 8h post onset of ischemia, then 4.5 mg/kg every 2h for 48h via i.p.).
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Xuegang He et al.
Experimental neurology, 361, 114301-114301 (2022-12-21)
Traumatic spinal cord injury (TSCI) is a serious nervous system insult, and apoptosis in secondary injury is an important barrier to recovery from TSCI. Heat shock protein family A member 1A (HSPA1A) is a protective protein whose expression is elevated
Anookh Mohanan et al.
Neuropharmacology, 60(6), 991-999 (2010-12-21)
Induction of HSPs is a natural response of stressed cells that protects against many insults including acute ischemia. TRC051384, a novel compound belonging to substituted 2-propen-1-one class is a potent inducer of heat shock protein 70 (HSP70). The aim of
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Cardiovascular research, 110(3), 309-318 (2016-03-16)
Atrial fibrillation (AF) is a major risk factor for cardio-embolic stroke. Anticoagulant drugs are effective in preventing AF-related stroke. However, the high frequency of anticoagulant-associated major bleeding is a major concern. This study sought to identify new targets to develop
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