SMILES string
CN1CCN(C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCC3=CC=CC=C3)/C=C/S(C4=CC=CC=C4)(=O)=O)=O)=O)CC1
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Quality Level
Biochem/physiol Actions
Orally bioavailable, non-toxic, covalent inactivator of cathepsin L and other cysteine proteases including Schistosoma mansoni SmCB1 and cruzain; reduces SARS-CoV-2 viral infectivity with no effect on PLpro and Mpro.
K11777 is an orally bioavailable, non-toxic, dipeptidyl vinyl-sulfone analog that acts as a potent, covalent inactivator of cathepsin L and other cysteine proteases. Reduces SARS-CoV-2 viral infectivity (EC50 = 74, <80 and 4 nM for Vero E6, A549/ACE2, and HeLa/ACE2 cells, respectively) with no effect on papain-like (PLpro) and 3CL cysteine proteases (Mpro), encoded by SARS-CoV-2 at ≤ 100 µM. K11777 inhibits Schistosoma mansoni cathepsin B1 (SmCB1) and cruzain. Displays broad-spectrum anti-parasitic activities.
K11777 is an orally bioavailable, non-toxic, dipeptidyl vinyl-sulfone analog that acts as a potent, covalent inactivator of cathepsin L and other cysteine proteases. Reduces SARS-CoV-2 viral infectivity (EC50 = 74, <80 and 4 nM for Vero E6, A549/ACE2, and HeLa/ACE2 cells, respectively) with no effect on papain-like (PLpro) and 3CL cysteine proteases (Mpro), encoded by SARS-CoV-2 at ≤ 100 µM. K11777 inhibits Schistosoma mansoni cathepsin B1 (SmCB1) and cruzain. Displays broad-spectrum anti-parasitic activities.
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