SML4048

LEI-102

Name: LEI-102
Brand: SIGMA

≥95% (HPLC)

别名:

1-[[4-[5-Fluoro-6-[[(tetrahydro-2H-pyran-4-yl)amino]methyl]-2-pyridinyl]phenyl]methyl]-3-(2-methylpropyl)-2,4-imidazolidinedione

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关于此项目

经验公式（希尔记法）:

C₂₅H₃₁FN₄O₃

化学文摘社编号:

1228659-40-2

分子量:

454.54

NACRES:

NA.21

Assay:

≥95% (HPLC)

Form:

powder

Quality level:

100

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SMILES string

O=C(N1CC(C)C)N(CC2=CC=C(C=C2)C3=CC=C(C(CNC4CCOCC4)=N3)F)CC1=O

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Orally available potent and selective cannabinoid CB2 receptor agonist.
LEI-102 is orally available, highly potent and highly selective cannabinoid CB2 receptor agonist. LEI-102 attenuates cisplatin-induced nephrotoxicity in mice. LEI-102 did not generate CB1R-mediated CNS-side effects at doses up to 25mg/kg (p.o.) in mice model.