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SML4074

Trabectedin

Name: Trabectedin
Brand: SIGMA

≥98% (HPLC)

别名:

(1′R,6R,6aR,7R,13S,14S,16R)-6′,8,14-Trihydroxy-7′,9-dimethoxy-4,10,23-trimethyl-19-oxo-3′,4′,6,7,12,13,14,16-octahydrospiro(6,16-(epithiopropanooxymethano)-7,13-imino-6aH-1,3-dioxolo(7,8)isoquino(3,2-b)(3)benzazocine-20,1′(2′H)-isoquinolin)-5-yl acetate, 1′R,6R,6aR,7R,13S,14S,16R)-5-(Acetyloxy)-3′,4′,6,6a,7,13,14,16-octahydro-6′,8,14-trihydroxy-7′,9-dimethoxy-4,10,23-trimethylspiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1′(2′H)-isoquinolin]-19-one, ET-743, Ecteinascidin 743

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经验公式（希尔记法）:

C₃₉H₄₃N₃O₁₁S

化学文摘社编号:

114899-77-3

分子量:

761.84

NACRES:

NA.21

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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属性

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

SMILES string

CC(C1=C2OCO1)=C(OC(C)=O)C3=C2[C@H](CO4)N([C@@H](O)[C@H]5N(C)[C@@H]6C7=C(C5)C=C(C)C(OC)=C7O)C6[C@H]3SC[C@@]8(C4=O)NCCC9=C8C=C(OC)C(O)=C9

InChI

1S/C39H43N3O11S/c1-16-9-20-10-22-37(46)42-23-13-50-38(47)39(21-12-25(48-5)24(44)11-19(21)7-8-40-39)14-54-36(30(42)29(41(22)4)26(20)31(45)32(16)49-6)28-27(23)35-34(51-15-52-35)17(2)33(28)53-18(3)43/h9,11-12,22-23,29-30,36-37,40,44-46H,7-8,10,13-15H2,1-6H3/

InChI key

PKVRCIRHQMSYJX-CXIMGACLSA-N

说明

Biochem/physiol Actions

Anti-proliferative; a potent anticancer agent.

Trabectedin is an alkylating drug that binds guanine residues in the minor groove of DNA, causing RNA polymerase II arrest, interfering with transcription and DNA repair pathways. It is anti-proliferative, a potent anticancer agent that has been approved to treat advanced soft tissue sarcoma and is being investigated for treatment of multiple other cancers.

pictograms

GHS08

signalword

Danger

hcodes

H340,H361fd,H373

pcodes

P202 - P260 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Muta. 1B - Repr. 2 - STOT RE 2 Inhalation

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Ecteinascidins. A review of the chemistry, biology and clinical utility of potent tetrahydroisoquinoline antitumor antibiotics.

V H Le et al.

Natural product reports, 32(2), 328-347 (2014-10-03)

The ecteinascidin family comprises a number of biologically active compounds, containing two to three tetrahydroisoquinoline subunits. Although isolated from marine tunicates, these compounds share a common pentacyclic core with several antimicrobial compounds found in terrestrial bacteria. Among the tetrahydroisoquinoline natural

In ovarian cancer maraviroc potentiates the antitumoral activity and further inhibits the formation of a tumor-promoting microenvironment by trabectedin.

Naike Casagrande et al.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 172, 116296-116296 (2024-02-22)

Ovarian cancer (OC) is the fifth most frequent cause of cancer-related death in women. Chemotherapy agent trabectedin, affecting cancer cells and tumor microenvironment, has been approved for the treatment of relapsed platinum-sensitive OC patients. CCR5-antagonist maraviroc inhibits tumor growth, metastasis

全球贸易项目编号

货号	GTIN
SML4074-5MG	04065272112345
SML4074-25MG	04065272112338

主要文件

Trabectedin

≥98% (HPLC)

选择尺寸

关于此项目

Quality Level

assay

form

color

solubility

storage temp.

SMILES string

InChI

InChI key

Biochem/physiol Actions

安全信息

pictograms

signalword

hcodes

pcodes

Hazard Classifications

存储类别

wgk

flash_point_f

flash_point_c

法规信息

文件

分析证书(COA)

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