SMILES string
Fc1cc(ccc1)C(=O)N\N=C\c2[s]c(cc2)[N+](=O)[O-]
InChI
1S/C12H8FN3O3S/c13-9-3-1-2-8(6-9)12(17)15-14-7-10-4-5-11(20-10)16(18)19/h1-7H,(H,15,17)/b14-7+
InChI key
QDYQZMWFIYLMNX-VGOFMYFVSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Mitochondrial import blocker of substances requiring inner membrane translocon TIM23.
MitoBloCK-10 (MB-10) is mitochondrial import blocker of substances requiring inner membrane translocon TIM23 (TIM23) in yeast and mammalian mitochondria. It appears that MB-10 targets Tim44 of the PAM complex. MitoBloCK-10 does not alter respiraton. MB-10 inhibits cardiac development and induces apoptosis in Zebrafish embryos. It inhibits bladder cancer cell growth in vitro and in vivo.
MitoBloCK-10 (MB-10) is mitochondrial import blocker of substances requiring inner membrane translocon TIM23 (TIM23) in yeast and mammalian mitochondria. It appears that MB-10 targets Tim44 of the PAM complex. MitoBloCK-10 does not alter respiraton. MB-10 inhibits cardiac development and induces apoptosis in Zebrafish embryos. It inhibits bladder cancer cell growth in vitro and in vivo.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Non Miyata et al.
The Journal of biological chemistry, 292(13), 5429-5442 (2017-02-09)
Diverse protein import pathways into mitochondria use translocons on the outer membrane (TOM) and inner membrane (TIM). We adapted a genetic screen, based on Ura3 mistargeting from mitochondria to the cytosol, to identify small molecules that attenuated protein import. Small
A first-in-class TIMM44 blocker inhibits bladder cancer cell growth
Cell Death & Disease, 15(3), 204-204 (2024)
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