跳转至内容
Merck
CN

主要文件

查看所有文档

SML4091

SGC-CDKL5/GSK3-1

≥98% (HPLC)

别名:

4-(3,5-Difluorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide, 4-[(3,5-Difluorobenzoyl)amino]-N-4-piperidinyl-1H-pyrazole-3-carboxamide

登录 查看组织和合同定价。

选择尺寸

变更视图

关于此项目

经验公式（希尔记法）:
C16H17F2N5O2
化学文摘社编号:
844442-32-6
分子量:
349.34
NACRES:
NA.28
Assay:
≥98% (HPLC)
Form:
powder
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(NC1CCNCC1)C2=NNC=C2NC(C3=CC(F)=CC(F)=C3)=O

Biochem/physiol Actions

Potent cyclin-dependent kinase-like 5 (CDKL5) and glycogen synthase kinase-3 (GSK3⍺/β) inhibitor with good kinome-wide selectivity.
SGC-CDKL5/GSK3-1 is a potent cyclin-dependent kinase-like 5 and glycogen synthase kinase-3 inhibitor (CDKL5/GSK3⍺/GSK3β IC50 = 6.5/4/9 nM by cell-free enzymatic assay, 3.5/10/35 nM by cellular NanoBRET) with good kinome-wide selectivity. SGC-CDKL5/GSK3-1 protects iPSC-derived motor neurons from ER stress-induced death.

Hazard Classifications

Acute Tox. 4 Oral

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our 文件 section.

如需帮助，请联系 客户支持

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库