SMILES string
O=C(NCC1CCOCC1)C2=NNC=C2NC(C3=C(C=CC=C3F)F)=O
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Potent and selective glycogen synthase kinase-3 (GSK3⍺/β) inhibitor.
SGC-GSK3-1 is a potent and selective glycogen synthase kinase-3 inhibitor (GSK3⍺/β IC50 = 1/2 nM by cell-free enzymatic assay, 4.6/12 nM by cellular NanoBRET) that protects iPSC-derived motor neurons from ER stress-induced death.
SGC-GSK3-1 is a potent and selective glycogen synthase kinase-3 inhibitor (GSK3⍺/β IC50 = 1/2 nM by cell-free enzymatic assay, 4.6/12 nM by cellular NanoBRET) that protects iPSC-derived motor neurons from ER stress-induced death.
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