SGC-GSK3-1

Name: SGC-GSK3-1
Brand: SIGMA

≥98% (HPLC)

别名:

4-(2,6-Difluorobenzamido)-N-((tetrahydro-2H-pyran-4-yl)methyl)-1H-pyrazole-3-carboxamide

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关于此项目

经验公式（希尔记法）:

C₁₇H₁₈F₂N₄O₃

化学文摘社编号:

844441-56-1

分子量:

364.35

NACRES:

NA.28

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(NCC1CCOCC1)C2=NNC=C2NC(C3=C(C=CC=C3F)F)=O

Biochem/physiol Actions

Potent and selective glycogen synthase kinase-3 (GSK3⍺/β) inhibitor.

SGC-GSK3-1 is a potent and selective glycogen synthase kinase-3 inhibitor (GSK3⍺/β IC50 = 1/2 nM by cell-free enzymatic assay, 4.6/12 nM by cellular NanoBRET) that protects iPSC-derived motor neurons from ER stress-induced death.