SMILES string
O=C(C1=C(/C=N/NC(NC(C)(C)C)=S)N(C2=CC=C(C=C2F)F)N=C1)OC
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Quality Level
Biochem/physiol Actions
Potent and human GPR35-selective antagonist that effectively blocks agonist-induced cellular responses without significant effect toward rat or mouse GPR35.
CID 2745687 is a potent and human GPR35-selective antagonist that effectively blocks agonist pamoic acid (PA)-induced cellular responses using human HA-GPR35a-expressing U2OS transfectants (Ki = 12.8 or 18 nM against 1 µM PA by βarr2-GFP recruitment and ERK1/2 phosphorylation, respectively), while exhibiting no significant effect toward rat or mouse GPR35. CID 2745687 is competitive against cromolyn disodium and zaprinast, while being noncompetitive against PA.
CID 2745687 is a potent and human GPR35-selective antagonist that effectively blocks agonist pamoic acid (PA)-induced cellular responses using human HA-GPR35a-expressing U2OS transfectants (Ki = 12.8 or 18 nM against 1 µM PA by βarr2-GFP recruitment and ERK1/2 phosphorylation, respectively), while exhibiting no significant effect toward rat or mouse GPR35. CID 2745687 is competitive against cromolyn disodium and zaprinast, while being noncompetitive against PA.
法规信息
新产品
此项目有
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持