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关于此项目
经验公式（希尔记法）:
C17H19F2N5O2S
化学文摘社编号:
分子量:
395.43
MDL number:
NACRES:
NA.28
UNSPSC Code:
12352203
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
SMILES string
O=C(C1=C(/C=N/NC(NC(C)(C)C)=S)N(C2=CC=C(C=C2F)F)N=C1)OC
Biochem/physiol Actions
Potent and human GPR35-selective antagonist that effectively blocks agonist-induced cellular responses without significant effect toward rat or mouse GPR35.
CID 2745687 is a potent and human GPR35-selective antagonist that effectively blocks agonist pamoic acid (PA)-induced cellular responses using human HA-GPR35a-expressing U2OS transfectants (Ki = 12.8 or 18 nM against 1 µM PA by βarr2-GFP recruitment and ERK1/2 phosphorylation, respectively), while exhibiting no significant effect toward rat or mouse GPR35. CID 2745687 is competitive against cromolyn disodium and zaprinast, while being noncompetitive against PA.
CID 2745687 is a potent and human GPR35-selective antagonist that effectively blocks agonist pamoic acid (PA)-induced cellular responses using human HA-GPR35a-expressing U2OS transfectants (Ki = 12.8 or 18 nM against 1 µM PA by βarr2-GFP recruitment and ERK1/2 phosphorylation, respectively), while exhibiting no significant effect toward rat or mouse GPR35. CID 2745687 is competitive against cromolyn disodium and zaprinast, while being noncompetitive against PA.
警示词
Warning
危险代码
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
怎么回事？
WGK 3
闪点 (F)
Not applicable
闪点 (°C)
Not applicable