SMILES string
OS(=O)(C)=O.CCCCOCCOC(C=C1)=CC=C1C2=CC=C3C(/C=C(C(NC4=CC=C([S@@+]([O-])CC5=CN=CN5CCC)C=C4)=O)\CCCN3CC(C)C)=C2
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
, faint green to green brown
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Quality Level
Biochem/physiol Actions
Orraly active inhibitor of CCR2 and CCR5 receptors; Antiretroviral entry inhibitor.
Cenicriviroc is an orally available inhibitor of C-C chemokine CCR2 (IC50 = 5.9 nM) and CCR5 (IC50 = 0.29 nM) receptors, an antiretroviral entry inhibitor with anti-inflammatory activity. CCR5 chemokine receptor antagonists are believed to inhibit HIV entry by blocking interaction of viral coat protein gp120 with the receptor. CCR2 is involved with inflammatory-related disease states.
Cenicriviroc is an orally available inhibitor of C-C chemokine CCR2 (IC50 = 5.9 nM) and CCR5 (IC50 = 0.29 nM) receptors, an antiretroviral entry inhibitor with anti-inflammatory activity. CCR5 chemokine receptor antagonists are believed to inhibit HIV entry by blocking interaction of viral coat protein gp120 with the receptor. CCR2 is involved with inflammatory-related disease states.
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