SML4113
OGT2115
≥97% (HPLC)
别名:
2-[4-[[3-(4-Bromophenyl)-1-oxo-2-propen-1-yl]amino]-3-fluorophenyl]-5-benzoxazoleacetic acid, 2-[4-[[3-(4-Bromophenyl)-1-oxo-2-propenyl]amino]-3-fluorophenyl]-5-benzoxazoleacetic acid, OGT 2115, OGT-2115
质量水平
方案
≥97% (HPLC)
表单
powder
颜色
white to beige
溶解性
soluble (DMSO:0.1M NaOH (95:5), 1.0 mg/mL, clear, warmed, may need to sonicate.)
储存温度
-10 to -25°C
生化/生理作用
Heparanase (HPSE) inhibitor with anti-angiogenesis potency and no inhibition of major human cytochrome P450 enzymes.
OGT 2115 is a heparanase (HPSE) inhibitor (IC50 = 0.4 μM) with anti-angiogenesis potency in human endothelial cell cultures (tubule formation IC50 = 1 μM) and no inhibition of major human cytochrome P450 enzymes (Cyp3A4 & Cyp2C9 IC50 > 30 μM).
OGT 2115 is a heparanase (HPSE) inhibitor (IC50 = 0.4 μM) with anti-angiogenesis potency in human endothelial cell cultures (tubule formation IC50 = 1 μM) and no inhibition of major human cytochrome P450 enzymes (Cyp3A4 & Cyp2C9 IC50 > 30 μM).
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