SML4116
Orai1 Agonist, IA65
≥95% (HPLC)
别名:
4-((5-Phenyl-4-(trifluoromethyl)thiazol-2-yl)amino)benzoic acid, 4-[[5-Phenyl-4-(trifluoromethyl)-2-thiazolyl]amino]benzoic acid, IA65
质量水平
方案
≥95% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
O=C(C1=CC=C(NC2=NC(C(F)(F)F)=C(C3=CC=CC=C3)S2)C=C1)O
生化/生理作用
Selective Orai1 and SOCE (store-operated Ca2+ entry) potentiator that marginally affects Orai2 and Orai3.
Orai1 Agonist IA65 is a selective Orai1 and SOCE (store-operated Ca2+ entry) potentiator that preferentially occupies Oari1 N-terminal domain binding pocket and significantly enhances Orai1-mediated Ca2+-influx and concurrently potentiates Orai1 Ca2+-dependent inactivation (CDI) with an EC50 of 1.9 uM. IA65 mildly potentiates ORAI3-mediated ICRAC with a slight inhibition of ICRAC mediated by ORAI2. Increases Orai1 activity in VSMCs and skeletal muscle fibers in a concentration-dependent manner. IA-65 is shown to be inactive against TRPV1, TRPM8, or CaV2.2 and nontoxic up to 100 uM.
Orai1 Agonist IA65 is a selective Orai1 and SOCE (store-operated Ca2+ entry) potentiator that preferentially occupies Oari1 N-terminal domain binding pocket and significantly enhances Orai1-mediated Ca2+-influx and concurrently potentiates Orai1 Ca2+-dependent inactivation (CDI) with an EC50 of 1.9 uM. IA65 mildly potentiates ORAI3-mediated ICRAC with a slight inhibition of ICRAC mediated by ORAI2. Increases Orai1 activity in VSMCs and skeletal muscle fibers in a concentration-dependent manner. IA-65 is shown to be inactive against TRPV1, TRPM8, or CaV2.2 and nontoxic up to 100 uM.
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
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