SML4127
BRD0539
≥98% (HPLC)
别名:
((3aR,4R,9bR)-8-(2-fluorophenyl)-1-tosyl-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-c]quinolin-4-yl)methanol, (3aR,4R,9bR)-8-(2-Fluorophenyl)-2,3,3a,4,5,9b-hexahydro-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[3,2-c]quinoline-4-methanol
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
-10 to -25°C
SMILES字符串
OC[C@@H]1NC2=CC=C(C3=C(F)C=CC=C3)C=C2[C@H]4[C@@H]1CCN4S(C5=CC=C(C)C=C5)(=O)=O
生化/生理作用
Cell penetrant and potent anti-CRISPR agent that inhibits SpCas9-DNA interaction.
BRD0539 is a cell penetrant and potent anti-CRISPR agent. BRD0539 is a reversible inhibitor of Streptococcus pyogenes Cas9 (SpCas9) that disrupt the SpCas9-DNA interaction. It potently inhibits SpCas9/PAM binding leading to a decrease in nuclease activity. BRD0539 is stable under physiological conditions.
BRD0539 is a cell penetrant and potent anti-CRISPR agent. BRD0539 is a reversible inhibitor of Streptococcus pyogenes Cas9 (SpCas9) that disrupt the SpCas9-DNA interaction. It potently inhibits SpCas9/PAM binding leading to a decrease in nuclease activity. BRD0539 is stable under physiological conditions.
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
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