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SML4127

BRD0539

≥98% (HPLC)

别名:

((3aR,4R,9bR)-8-(2-fluorophenyl)-1-tosyl-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-c]quinolin-4-yl)methanol, (3aR,4R,9bR)-8-(2-Fluorophenyl)-2,3,3a,4,5,9b-hexahydro-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[3,2-c]quinoline-4-methanol

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关于此项目

经验公式（希尔记法）:
C25H25FN2O3S
化学文摘社编号:
1403838-79-8
分子量:
452.54
MDL number:
MFCD32709969
NACRES:
NA.28
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

SMILES string

OC[C@@H]1NC2=CC=C(C3=C(F)C=CC=C3)C=C2[C@H]4[C@@H]1CCN4S(C5=CC=C(C)C=C5)(=O)=O

Biochem/physiol Actions

Cell penetrant and potent anti-CRISPR agent that inhibits SpCas9-DNA interaction.


BRD0539 is a cell penetrant and potent anti-CRISPR agent. BRD0539 is a reversible inhibitor of Streptococcus pyogenes Cas9 (SpCas9) that disrupt the SpCas9-DNA interaction. It potently inhibits SpCas9/PAM binding leading to a decrease in nuclease activity. BRD0539 is stable under physiological conditions.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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