SMILES string
OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CNC.ClC1=CC(Cl)=CC(C(OC2=C3)=NC2=CC=C3C(O)=O)=C1
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to pink
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Transthyretin (TTR) tetramer stabilizer.
Tafamidis is a transthyretin (TTR) tetramer stabilizer that binds selectively and with negative cooperativity to the two normally unoccupied thyroxine-binding sites of the tetramer (Kd ~2 nM and ~200 nM), kinetically stabilizing the wild-type as well as the variant TTR complexes (V30M, F64S, Y69H, I84S, V122I, and L111M) and preventing their dissociation into fibril-forming monomers.
Tafamidis is a transthyretin (TTR) tetramer stabilizer that binds selectively and with negative cooperativity to the two normally unoccupied thyroxine-binding sites of the tetramer (Kd ~2 nM and ~200 nM), kinetically stabilizing the wild-type as well as the variant TTR complexes (V30M, F64S, Y69H, I84S, V122I, and L111M) and preventing their dissociation into fibril-forming monomers.
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