质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
CCN1C2=C(C=CC=C2)C3=CC(CNC4=NC5=C(N4C)C=CC=C5)=CC=C31
生化/生理作用
Cell penetrant, potent and selective first-in-class functional inhibitors of SLC15A4.
AJ2-30 is a cell penetrant, potent and selective first-in-class functional inhibitors of SLC15A4 (IC50 = 1.8 μM (IFN-α suppression) and IC50 = 2.6 μM (MDP transport inhibition)) that disrupt all functions of SLC15A4. AJ2-30 potently suppressed IFN-α production in human pDCs after stimulation with TLR7/8 and TLR9 agonists. It significantly suppressed production of IFN-γ, IL-6 and IL-10 in lupus patient-derived PBMCs, and significantly reduced IFN-α, IFN-β and IFN-γ production in mice.
AJ2-30 is a cell penetrant, potent and selective first-in-class functional inhibitors of SLC15A4 (IC50 = 1.8 μM (IFN-α suppression) and IC50 = 2.6 μM (MDP transport inhibition)) that disrupt all functions of SLC15A4. AJ2-30 potently suppressed IFN-α production in human pDCs after stimulation with TLR7/8 and TLR9 agonists. It significantly suppressed production of IFN-γ, IL-6 and IL-10 in lupus patient-derived PBMCs, and significantly reduced IFN-α, IFN-β and IFN-γ production in mice.
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