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关于此项目
经验公式（希尔记法）:
C19H14FNO
化学文摘社编号:
分子量:
291.32
MDL number:
NACRES:
NA.28
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
FC1=CC=C(C(NC2=CC=C3C4=C2C=CC=C4CC3)=O)C=C1
Biochem/physiol Actions
Uniquely acting, highly selective sub-type activator for the KCNQ2 (KV7.2) potassium channel.
Ebio1 is a potent, sub-type selective KCNQ2 (KV7.2) potassium channel direct activator that is distinct from previously known activators of voltage-gated ion channels. Ebio1 operates through a unique mechanism, inducing a twist-to-open movement in the S6 helices of the channel, thereby increasing both the open probability and conductance of KCNQ2. KCNQ2 Activator Ebio1 has an EC50 of 247.3 nM for KCNQ2, making it tenfold more selective compared to KCNQ2/3, KCNQ4, and KCNQ5. Moreover, Ebio1 demonstrates minimal to negligible activation effects on other tested Kv, Nav, Cav, and K2P channel members, including hERG, BK, Nav1.1, Cav2.1, and TREK1.
Ebio1 is a potent, sub-type selective KCNQ2 (KV7.2) potassium channel direct activator that is distinct from previously known activators of voltage-gated ion channels. Ebio1 operates through a unique mechanism, inducing a twist-to-open movement in the S6 helices of the channel, thereby increasing both the open probability and conductance of KCNQ2. KCNQ2 Activator Ebio1 has an EC50 of 247.3 nM for KCNQ2, making it tenfold more selective compared to KCNQ2/3, KCNQ4, and KCNQ5. Moreover, Ebio1 demonstrates minimal to negligible activation effects on other tested Kv, Nav, Cav, and K2P channel members, including hERG, BK, Nav1.1, Cav2.1, and TREK1.
存储类别
11 - Combustible Solids
怎么回事？
WGK 3
闪点 (F)
Not applicable
闪点 (°C)
Not applicable