LY341495

LY341495 is suitable for use as a metabotropic glutamate receptor antagonist to study the role of glutamate signaling in various physiological and pathological processes. It is used in neurobiology studies, particularly in understanding the mechanisms underlying synaptic transmission/ neurotransmitter release , synaptic plasticity and neuronal excitability.

Potent antagonist against group II metabotropic glutamate receptors mGluR2 and mGluR3. LY341495 (LY 341495,LY-341,495, LY-341495) is a group II metabotropic glutamate receptor antagonist that potently reverses 3 μM mGluR agonist ACPD-dependent inhibition of forskolin-induced cAMP production in cells expressing either human mGluR2 ormGluR3 (IC50 = 21 nM and 14 nM, respectively), being much less potent against mGluR8, mGluR7, mGluR1a, mGluR5a, and mGluR4 (IC50 = 0.17, 0.99, 7.8, 8.2, 22μM, respectively). LY341495 is widely used for studying mGluR2/3-dependent cellular and physiological functions both in cultures in vitro and in animals in vivo (1-10 mg/kg via i.p. or s.c.).