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关于此项目
经验公式（希尔记法）:
C17H18FN3O3·HCl · xH2O
化学文摘社编号:
分子量:
367.80 (anhydrous basis)
MDL number:
NACRES:
NA.21
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
SMILES string
O=C(C1=CN(C2CC2)C3=CC(N4CCNCC4)=C(C=C3C1=O)F)O.Cl.[xH2O]
Application
Ciprofloxacin hydrochloride hydrate is suitable for use in research to study antibiotic resistance mechanisms. It is also used to inhibit cell proliferation and to sensitize cells to TRAIL (TNF-related apoptosis-inducing ligand) -Induced apotosis.
Biochem/physiol Actions
Ciprofloxacinis a fluoroquinolone antibiotic with broad-spectrum activity, which killsbacteria by blocking DNA gyrase and type IV topoisomerase—critical enzymes forDNA replication and transcription—leading to cell death. It is effectiveagainst a broad array of both Gram-positive and Gram-negative bacteria, inaddition to Mycoplasmas. While the hydrochloride form of ciprofloxacin ishighly soluble in water, ciprofloxacin itself is only sparingly soluble inaqueous solutions.
Disclaimer
Hygroscopic Store with desiccant
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
George G Zhanel et al.
Treatments in respiratory medicine, 5(6), 437-465 (2006-12-13)
The new respiratory fluoroquinolones (gatifloxacin, gemifloxacin, levofloxacin, moxifloxacin, and on the horizon, garenoxacin) offer many improved qualities over older agents such as ciprofloxacin. These include retaining excellent activity against Gram-negative bacilli, with improved Gram-positive activity (including Streptococcus pneumoniae and Staphylococcus
G S Davies et al.
The Journal of antimicrobial chemotherapy, 16(6), 713-717 (1985-12-01)
Ciprofloxacin appears to have useful activity against Pseudomonas aeruginosa. We have studied its in-vitro activity against ten strains of Ps. aeruginosa with multiple antibiotic resistance. We have confirmed that ciprofloxacin is very active against Ps. aeruginosa with minimal inhibitory concentrations
Raizza Zorman Marques et al.
Environmental pollution (Barking, Essex : 1987), 357, 124376-124376 (2024-06-20)
We compared the ability of one emergent (Sagittaria montevidensis), two floating (Salvinia minima and Lemna gibba), and one heterophyllous species (Myriophyllum aquaticum) to simultaneously remove sulfamethoxazole, sulfadiazine, ciprofloxacin, enrofloxacin, norfloxacin, levofloxacin, oxytetracycline, tetracycline, doxycycline, azithromycin, amoxicillin, and meropenem from wastewater
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML4150-50MG | 04065272699426 |
| SML4150-10MG | 04065272699419 |